A woman may not be able to become an egg donor if STDs or certain abnormalities of the reproductive system are present.
Many egg donation programs prohibit smokers and those who are overweight. A woman that abuses drugs or alcohol, past or present, typically showcases a profile of previous medication use that modifies mental development, or a great deal of strain in her own personal life; involved in an unbalanced relationship or is not sufficiently able to understand the process of donating.
About 10 percent of women (6.1 million) in the United States ages 15-44 have difficulty getting pregnant or staying pregnant (Source: CDC, Centers for Disease Control and Prevention)
In this case, typically a potential candidate is not accepted as an egg donor.
Additionally, certain inheritable conditions or traits, such as sickle cell anemia will not be able to become an egg donor.
You are prohibited from donating eggs if you have introduced your body to illegal drugs or been involved in any form of prostitution within the last three years, identified with syphilis or been the recipient of acupuncture, tattoo or body piercing without sterile procedures established. The program typically requires your sexual partner to be confirmed HIV negative.
The donation screening process of becoming an egg donor can be a lengthy, meticulous process. Papers must be signed acknowledging consent that you understand the process of donating eggs and the risks involved, compensation provided, and any legal rights that you will have accompanying a child being born with your donated eggs.
When the screening process is completed and you are approved to become an egg donor, the fertility clinic will start the recipient matching process. When a match is completed, the actual egg donation process starts.
Source: